Naked monoclonal antibodies or mAbs bind to specific epitopes or target molecules on cells. Therapeutic uses of mAbs have been limited by several factors, including cancer cell specificity, tumor penetration, as well as manufacturing issues. BioAtla’s human CAB mAbs are optimized and expressed in our proprietary CIAO! system. CAB mAbs have a high Therapeutic Index because they are only active under the physiological conditions associated with disease. This unique capability enables development of therapeutics for targets that are also expressed on healthy tissues, while minimizing undesirable side effects.
BioAtla’s partner F1 Oncology is developing conditionally active Chimeric Antigen Receptor-T cell (CAR-T) therapies engineered by grafting single-chain variable fragments (scFv) from a Conditionally Active Biologic (CAB) antibody to a proprietary T cell signaling domain. These fusion molecules trigger T cell recognition and killing of cells expressing the cancer target in the tumor microenvironment. We believe the improved tumor specificity of these CAB-based CAR-Ts will improve their safety profile and ultimately help enable CAR-T treatment of solid tumors.
BioAtla®’s Conditionally Active Bispecific Antibodies (CAB-B’s) are engineered to selectively target two receptors on cancer cells, or provide an alternative way of recruiting immune cells to cancer tissue.