CAB Portfolio

ADC's &
MAB's
Immune Checkpoint Inhibitors
CAR-T & Bispecifics
cab-portfolio-wheel-panel-icon
16 Additional
candidates
Antibody Drug Conjugates & Naked mAbs
CAB-ADC antibodies aim to address the inherent limitations of current ADC antibody technology by actively binding to antigens expressed on cancer cells, but not to the same antigens expressed on normal cells in non-diseased tissues. This approach allows the preferential targeting of tumor tissues by ADCs, thereby increasing the efficacy to toxicity ratios (Therapeutic Index) of CAB-ADCs relative to their conventional counterparts. The use of CAB antibodies as payload delivery vehicles could dramatically increase the safety and number of tumor-associated antigens that are addressable with ADC technology.

Naked monoclonal antibodies or mAbs bind to specific epitopes or target molecules on cells.  Therapeutic uses of mAbs have been limited by several factors, including cancer cell specificity, tumor penetration, as well as manufacturing issues.  BioAtla’s human CAB mAbs are optimized and expressed in our proprietary CIAO! system.  CAB mAbs have a high Therapeutic Index because they are only active under the physiological conditions associated with disease.  This unique capability enables development of therapeutics for targets that are also expressed on healthy tissues, while minimizing undesirable side effects. 

Representative Cancer Indications
NSCLC
Breast
Pancreatic
Ovarian
Prostate
Esophageal
Liver
AML
AXL
AXL is a receptor tyrosine kinase and oncogene involved in the stimulation of cell proliferation and associated with a variety of cancers including pancreatic, colon cancer, melanoma, CML and others. Like many cancer targets AXL is over-expressed in cancer but can also be found in some normal tissues, which would cause toxicity if treated with conventional Antibody Drug Conjugates (ADC’s). BioAtla’s CAB anti-AXL ADC however specifically targets the tumor microenvironment, reducing toxicity in normal tissue.
Representative Cancer Indications
Osteosarcoma
Melanoma
Renal cell carcinoma
Gastrointestinal stromal tumor (GIST)
Colorectal
Pancreatic
NSCLC
ROR2
ROR2 is a receptor tyrosine kinase involved in Wnt signal transduction and thus in embryonic development and cancer. It is associated with cancers including osteosarcoma, melanoma, renal cell carcinoma, gastrointestinal stromal tumor (GIST), colorectal cancer, pancreatic ductal adenocarcinoma, and NSCLC. In many cancer types expression of ROR2 correlates with advanced stage of disease or poor prognosis.
Immune Checkpoint Inhibitors
BioAtla®’s CAB immune Checkpoint inhibitors and stimulators (CAB-C’s) are engineered to target either immune cells or tumor cells. CAB-C’s are active in selected microenvironments within the body and prevent tumor cells from inhibiting immune cells, thereby enabling the body's immune cells to remain activated. These activated immune cells can shrink the tumor, individually or in combination with other drugs, and may eradicate the cancer.
Representative Cancer Indications
Non small cell lung cancer (NSCLC)
Melanoma
CTLA4
Cytotoxic T Lymphocyte Associated Protein-4 (CTLA-4) is a receptor on the surface of helper T cells that binds CD80 and CD86 on antigen presenting cells, transmitting an inhibitory signal to T cells. By reversing this inhibition anti-CTLA-4 antibodies have been shown to have great benefit in treating cancer, but can also cause toxicity by activating T cells generally, especially in combination with other immune checkpoint antibodies. BioAtla’s CAB-CTLA4 antibody helps target this activation to the tumor microenvironment, reducing on-target toxicity and enabling more powerful and safer combination therapies.
CAR-T & Bispecifics

BioAtla’s partner F1 Oncology is developing conditionally active Chimeric Antigen Receptor-T cell (CAR-T) therapies engineered by grafting single-chain variable fragments (scFv) from a Conditionally Active Biologic (CAB) antibody to a proprietary T cell signaling domain. These fusion molecules trigger T cell recognition and killing of cells expressing the cancer target in the tumor microenvironment. We believe the improved tumor specificity of these CAB-based CAR-Ts will improve their safety profile and ultimately help enable CAR-T treatment of solid tumors.

BioAtla®’s Conditionally Active Bispecific Antibodies (CAB-B’s) are engineered to selectively target two receptors on cancer cells, or provide an alternative way of recruiting immune cells to cancer tissue.

AXL-CAR-T
AXL is a receptor tyrosine kinase and oncogene involved in the stimulation of cell proliferation and associated with a variety of cancers including pancreatic, colon cancer, melanoma, CML and others. Like many cancer targets AXL is over-expressed in cancer but can also be found in some normal tissues, which could cause toxicity if treated with a conventional AXL-CAR-T therapy. The CAB-AXL portion of F1 Oncology’s CAB-AXL-CAR-T however will enable specific targeting of AXL in the tumor microenvironment, and enhanced therapeutic window.
ROR2-CAR-T
ROR2 is a receptor tyrosine kinase involved in Wnt signal transduction and thus in embryonic development and cancer. It is associated with cancers including osteosarcoma, melanoma, renal cell carcinoma, gastrointestinal stromal tumor (GIST), colorectal cancer, pancreatic ductal adenocarcinoma, and NSCLC. In many cancer types expression of ROR2 correlates with advanced stage of disease or poor prognosis.