We’re pros when it comes to proteins.

Let us be your tour guide to the world of proteins. Whether you’re looking for protein expression optimization or novel technology allowing unprecedented exploration of protein space, we can show you the way. Our broad range of services and patented technologies are designed to deliver on the full spectrum of molecular evolution and protein engineering. Welcome to comprehensive protein services.

Protein Services Overview

Assay Development expertise delivered across a wide array of assay types.

ProATLA™ Protein Evolution and Engineering

services are delivered through our proprietary technologies for comprehensive mutagenesis, combinatorial protein synthesis, protein expression optimization and bioassay development.

ProATLA™ Evolution

platform allows you to enhance multiple enzyme and protein characteristics simultaneously such as binding affinity, protein folding, substrate specificity, pH performance, enantioselectivity, expression, stability and more.

Protein Expression and Purification

expertise to guide you in identifying the optimal expression system for a candidate protein, develop a process to produce proteins in scaleable systems or create a customized purification process for any protein.

Conditionally Active Proteins

is a core area of expertise for us. Evolve your proteins according to criteria you define such as temperature, pH, osmotic pressure, hydrophobicity and many other conditions. Conditionally Active Proteins allow unprecedented design of smart proteins.
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Comprehensive Positional Evolution (CPE)™

platform enables the comprehensive mapping of the in vivo effects of every individual codon change within the protein for all 63 potential codon changes at each position within the protein.

Combinatorial Protein Synthesis (CPS)™

allows the subsequent generation and in vivo selection of all permutations of improved individual codons for identification of the optimal combination or set of codon changes within a protein or antibody.

Synergy Evolution™ and FlexEvolution™

is designed to identify and engineer improvements in protein function that result from multiple simultaneous changes, especially proteins with high assay variability or other improvements intractable by standard single amino acid protein evolution strategies.
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Pathway Engineering

services that deliver efficient yield of metabolic products. Contact us for details and pricing.

Ask us about:

  • The ATLAcode™ real world codon optimization of proteins for expression in microbial, insect, plant, mammalian cell lines and various vector types using high-throughput in vivo testing
  • Our ATLAmax™ optimization of all expression system components including promoters, splice control regions, introns, up/downstream flanking sequences and host cell engineering
  • How our FlexEvolution™ approach can modify traditionally intractable protein characteristics such as solubility, aggregation, deimmunization, glycosylation design and pharmacokinetics
  • How our technology yields comprehensive data sets to enable maximum intellectual property protection
  • Other proprietary evolution platforms for your most challenging engineering projects

Let’s talk. Call us at 858-558-0708 ext. 0 for information, planning and pricing.